Search results for " fatigue"

A Model for Low-Cycle Fatigue in Micro-Structured Materials

2019

A microscale formulation for low-cycle fatigue degradation in heterogeneous materials is presented. The interface traction-separation law is modelled by a cohesive zone model for low-cycle fatigue analysis, which is developed in a consistent thermodynamic framework of elastic-plastic-damage mechanics with internal variables. A specific fatigue activation condition allows to model the material degradation related to the elastic-plastic cyclic loading conditions, with tractions levels lower than the static failure condition. A moving endurance surface, in the classic framework of kinematic hardening, enables a pure elastic behaviour without any fatigue degradation for low levels of cyclic tra…

A Thermodynamically Consistent CZM for Low-Cycle Fatigue Analysis

2018

A cohesive zone model for low-cycle fatigue analysis is developed in a consistent thermodynamic framework of elastic-plastic-damage mechanics with internal variable. A specific fatigue activation condition allows to model the material degradation related to the elastic-plastic cyclic loading conditions, with tractions levels lower than the damage activation condition. A moving endurance surface, in the classic framework of kinematic hardening, enables a pure elastic behavior without any fatigue degradation for low levels loading conditions.

A preliminary investigation about the observation of regional skin temperatures following cumulative training loads in triathletes during training ca…

2019

There are controversial results in the literature concerning the concept that cumulative training load could affect basal skin temperature in the days following training sessions. The objective was to measure skin temperature in triathletes during a training camp with cumulative training load. Ten male recreational triathletes involved in a training camp underwent measurements of perception of pain and fatigue (visual analogue scale), skin temperature (infrared thermography), and jump performance (counter movement jump test) before, one day, and two days after the beginning of the training camp. All measurements were performed before the breakfast. Jump height did not differ between the day…

On the estimation of the fatigue cycle distribution from spectral density data

1999

This paper deals with the fatigue life prediction of components and structures subjected to random fatigue, i.e. to cyclic loading whose amplitude varies in an essentially random manner. In particular, this study concentrates on the general problem of directly relating fatigue cycle distribution to the power spectral density (PSD) by means of closed-form expressions that avoid expensive digital simulations of the stress process. At present, all the methods proposed to achieve this objective are based on the use of a single parameter of the PSD. In this work, by numerical simulations and theoretical considerations, it is shown that the statistical distribution of fatigue cycles depends on f…

Chronic, but not acute, fatigue predicts self-reported attentional driving errors in mothers attending infant children

2019

AbstractMothers attending infant children usually experience high levels of fatigue, and fatigue has been shown to be related to car crashes through attentional errors, among other causes. The current study investigates the effects of fatigue on the attentional errors while driving of women attending infant children. A sample of 112 women—67 attending infant children and 45 not attending—filled out self-report questionnaires assessing acute fatigue, chronic fatigue, and attention-related driving errors. A mediational analysis showed that women attending infant children had higher levels of fatigue, and that chronic fatigue, but not acute fatigue, was related to attentional errors while driv…

Intra-neuronal Competition for Synaptic Partners Conserves the Amount of Dendritic Building Material

2017

Brain development requires correct targeting of multiple thousand synaptic terminals onto staggeringly complex dendritic arbors. The mechanisms by which input synapse numbers are matched to dendrite size, and by which synaptic inputs from different transmitter systems are correctly partitioned onto a postsynaptic arbor, are incompletely understood. By combining quantitative neuroanatomy with targeted genetic manipulation of synaptic input to an identified Drosophila neuron, we show that synaptic inputs of two different transmitter classes locally direct dendrite growth in a competitive manner. During development, the relative amounts of GABAergic and cholinergic synaptic drive shift dendrit…

Redox-related biomarkers in physical exercise

2021

Research in redox biology of exercise has made considerable advances in the last 70 years. Since the seminal study of George Pake's group calculating the content of free radicals in skeletal muscle in resting conditions in 1954, many discoveries have been made in the field. The first section of this review is devoted to highlight the main research findings and fundamental changes in the exercise redox biology discipline. It includes: i) the first steps in free radical research, ii) the relation between exercise and oxidative damage, iii) the redox regulation of muscle fatigue, iv) the sources of free radicals during muscle contractions, and v) the role of reactive oxygen species as regulato…

Identification of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-associated DNA methylation patterns.

2018

BackgroundMyalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex condition involving multiple organ systems and characterized by persistent/relapsing debilitating fatigue, immune dysfunction, neurological problems, and other symptoms not curable for at least 6 months. Disruption of DNA methylation patterns has been tied to various immune and neurological diseases; however, its status in ME/CFS remains uncertain. Our study aimed at identifying changes in the DNA methylation patterns that associate with ME/CFS.MethodsWe extracted genomic DNA from peripheral blood mononuclear cells from 13 ME/CFS study subjects and 12 healthy controls and measured global DNA methylation by EL…

PTEN recruitment controls synaptic and cognitive function in Alzheimer's models

2016

Dyshomeostasis of amyloid-β peptide (Aβ) is responsible for synaptic malfunctions leading to cognitive deficits ranging from mild impairment to full-blown dementia in Alzheimer's disease. Aβ appears to skew synaptic plasticity events toward depression. We found that inhibition of PTEN, a lipid phosphatase that is essential to long-term depression, rescued normal synaptic function and cognition in cellular and animal models of Alzheimer's disease. Conversely, transgenic mice that overexpressed PTEN displayed synaptic depression that mimicked and occluded Aβ-induced depression. Mechanistically, Aβ triggers a PDZ-dependent recruitment of PTEN into the postsynaptic compartment. Using a PTEN kno…

2019

Foam rolling is thought to improve muscular performance and flexibility as well as to alleviate muscle fatigue and soreness. For this reason, foam rolling has become a popular intervention in all kinds of sport settings used to increase the efficiency of training or competition preparation as well as to speed post-exercise recovery. The objective of this meta-analysis was to compare the effects of foam rolling applied before (pre-rolling as a warm-up activity) and after (post-rolling as a recovery strategy) exercise on sprint, jump, and strength performance as well as on flexibility and muscle pain outcomes and to identify whether self-massage with a foam roller or a roller massager is more…